The Arizona Cardinals (3-6) and Los Angeles Rams (3-5) will meet on Sunday afternoon as both teams attempt to get their frustrating seasons back on track. Kickoff from SoFi Stadium will be at 4:25 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Cardinals vs. Rams odds, and make our expert NFL picks and predictions.
The Cardinals have lost 4 of their last 5 games after starting the year 2-2, dropping their last 2 against the Minnesota Vikings and Seattle Seahawks. Their defense has allowed the 2nd-most points per game (26.8) in the NFL this season and only ranks 16th in points scored (22.6). The Cardinals already lost once to the Rams this season, falling 20-12 in Week 3.
The Rams have been equally disappointing, starting the year 3-5 after losing their last 2 games to the San Francisco 49ers and Tampa Bay Buccaneers. The defense has allowed the 8th-fewest yards per game (312.4) but the offense is scoring just 16.4 points per game, which is 29th.
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Cardinals at Rams odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:24 a.m. ET.
- Moneyline (ML): Cardinals +110 (bet $100 to win $110) | Rams -130 (bet $130 to win $100)
- Against the spread (ATS): Cardinals +2.5 (-109) | Rams -2.5 (-111)
- Over/Under (O/U): 39.5 (O: -113 | U: -107)
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Cardinals at Rams key injuries
Cardinals
- S Budda Baker (ankle) questionable
- OL Max Garcia (shoulder) out
- OL Rodney Hudson (knee) out
- OT D.J. Humphries (back) questionable
- QB Kyler Murray (hamstring) questionable
Rams
- NT Greg Gaines (elbow) doubtful
- LT Alaric Jackson (knee) doubtful
- CB Robert Rochell (illness) questionable
- QB Matthew Stafford (concussion) questionable
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Cardinals at Rams picks and predictions
Prediction
Rams 21, Cardinals 17
Moneyline
With question marks about both teams’ quarterbacks, it’s hard to predict what either offense will look like on Sunday. If both are healthy and active, I like the Rams straight-up at home against a team they’re 11-1 against since 2017. However, if the Rams are without Stafford, this is a toss-up.
With so much uncertainty surrounding these teams, I’m going to PASS on the moneyline.
Against the spread
The Cardinals are currently +2.5 with Murray and Stafford questionable. The Rams opened as 3.5-point favorites before the quarterback injuries were reported earlier this week.
Murray seems to have a better chance to play than Stafford because of the fact that Stafford is in the concussion protocol, so I would take the CARDINALS +2.5 (-109) as of now.
Over/Under
The Over/Under opened at 43 points but has since dropped to 39.5 due to injury concerns. Regardless of which quarterback(s) play on Sunday, I like the UNDER 39.5 (-107) in this game. These offenses are just struggling too badly right now.
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