Arizona Cardinals at Los Angeles Rams odds, picks and prediction

Analyzing Sunday’s Arizona Cardinals at Los Angeles Rams odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (3-0) carry their unblemished record into Sunday’s matchup with the undefeated Los Angeles Rams (3-0), for a big early-season NFC West tilt at SoFi Stadium. Kickoff is set for 4:05 p.m. ET. Below, we look at the Cardinals vs. Rams odds and lines, and make our best NFL picks, predictions and bets.

The Cardinals are off to a fantastic start, winning each of their first three games. They lead the NFL in scoring with an average of 34.3 points per game, also checking in at No. 11 in total defense. QB Kyler Murray already has 10 total touchdowns and is averaging 335 passing yards per game, emerging as an MVP frontrunner in the early part of the season.

The Rams have been equally impressive. New QB Matthew Stafford has 9 touchdowns and just 1 interception, looking every bit like the star the Rams thought he’d be when they acquired him. The defense has played well, too, limiting the Tampa Bay Buccaneers to only 24 points – including a late garbage-time touchdown – last week.

Also see: Week 4 staff picks

Cardinals at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 5:15 p.m. ET.

  • Money line: Cardinals +175 (bet $100 to win $175) | Rams -220 (bet $220 to win $100)
  • Against the spread (ATS): Cardinals +4.5 (-108) | Rams -4.5 (-112)
  • Over/Under (O/U): 54.5 (O: -105 | U: -115)

PLAY: Try our new, free daily Pick’em Challenge and win. Play now!

Cardinals at Rams key injuries

Cardinals

  • OT Kelvin Beachum (ribs) questionable
  • OL Justin Murray (back) questionable
  • OL Justin Pugh (back) questionable
  • RB Eno Benjamin (hamstring) out

Rams

  • RB Darrell Henderson Jr. (ribs) questionable
  • WR Tutu Atwell (illness) doubtful

WIN YOUR FANTASY FOOTBALL LEAGUE!

For 25 years, TheHuddle.com has been helping fantasy players just like you win. This year, it’s your turn! Custom player rankings, tools and more to give you the edge over your competition.

Use code SBW21 to take 20% OFF a new subscription. Join now!

Cardinals at Rams odds, lines, predictions and picks

Prediction

Rams 30, Cardinals 27

Money line

The Rams are 8-0 against the Cardinals since 2017 and have outscored them 251-91. It’s as lopsided as any head-to-head matchup of the last four seasons, with Los Angeles owning Arizona since Sean McVay took over as head coach.

This is a much better Cardinals team than the one the Rams crushed in the last four years, but Los Angeles is still the better group on paper and on the field.

Bet the RAMS (-220) to win outright at home.

Against the spread

The Rams and Cardinals are both 2-1 ATS, each with two double-digit wins and another by just 3 or fewer points. Although there have been seven double-digit wins by the Rams in the last eight games against Arizona, I expect this one to be closer.

Bet the CARDINALS +4.5 (-108) to cover the spread and keep this one within a field goal.

Over/Under

The total has gone Over in each of the Rams’ first three games, mostly because the offense has scored on more than half of their possessions thus far. The Cardinals have the highest-scoring offense in the league and can be susceptible to the run on defense, which is why the line is on the higher side.

Bet the OVER 54.5 (-105).

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com. Please gamble responsibly.

Follow @camdasilva on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

Access more NFL coverage:

TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWireTitansWire | VikingsWire | WashingtonFootballWire | DraftWire | TouchdownWire | TheListWire

Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1367]