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The New England Patriots (3-11) will visit the Buffalo Bills (11-3) Sunday for a Week 16 AFC East showdown. Opening kickoff at Highmark Stadium is scheduled for 1 p.m. ET (CBS). Below, we look at Patriots vs. Bills odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.
The Patriots lost 30-17 as 6-point underdogs at the Arizona Cardinals Sunday in Week 15 with the Over (46) squeaking in. New England trailed throughout, getting outscored 10-0 in the opening quarter. The Pats now head to Western New York with a 4-game losing streak in tow.
In a marquee Week 15 matchup, the Bills defeated the Detroit Lions 48-42 Sunday. Buffalo looked impressive as 2.5-point road underdogs with the Over (55.5) cashing. Buffalo QB Josh Allen threw for 362 yards with 2 TDs, while also running for 68 yards with 2 more scores. It was the second straight game with both sides scoring 40-plus — the Bills lost at the LA Rams 44-42 in Week 14.
Sunday’s contest will mark the first of 2 between the Pats and Bills in a 3-week span. They close out their regular-season schedules with a Week 18 game at New England.
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Patriots at Bills odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 3:49 a.m. ET.
- Moneyline: Patriots +600 (bet $100 to win $600) | Bills -900 (bet $900 to win $100)
- Against the spread (ATS): Patriots +14 (-110) | Bills -14 (-110)
- Over/Under (O/U): 46.5 (O: -110 | U: -110)
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2024 betting stats
- ML: Patriots 3-11 | Bills 11-3
- ATS: Patriots 5-8-1 | Bills 9-5
- O/U: Patriots 9-5 | Bills 9-4-1
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Patriots vs. Bills head-to-head
New England leads the all-time series 78-50-1. The series began in 1960 and includes a 1-1 split in playoff games.
Buffalo took the most recent meeting 27-21 in Week 17 of last season, but didn’t cover as a 14.5-point home favorite. The Bills have won 5 of the last 6 games with the loss a 29-25 stunner as 8.5-point road favorites in Week 7 last year.
The Patriots are 38-26-1 across 65 series meetings held in Buffalo.
As mentioned, New England covered the spread in both games last season, following a Buffalo 4-0 ATS run. The last 10 meetings have netted a 5-5 split ATS.
The Over has cashed in 3 straight New England-Buffalo games and is 7-2-1 across the last 10 meetings.
The last 3 matchups at Highmark Stadium have resulted in the Bills covering twice and the Over hitting each time.
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