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The Michigan Wolverines (6-5, 4-4 Big Ten) and No. 2 Ohio State Buckeyes (10-1, 7-1) meet Saturday. Kickoff from Ohio Stadium is scheduled for noon ET (FOX). Let’s analyze BetMGM Sportsbook’s college football odds around the Michigan vs. Ohio State odds, and make our expert college football picks and predictions.
Michigan leads the all-time series 61-51-6, with the Wolverines winning the previous 3 meetings, including a 45-23 win Nov. 26, 2022, in the most recent battle in Columbus.
The Wolverines won the national championship last season, but fell on hard times in 2024 after coach Jim Harbaugh bolted for the NFL.
Michigan is bowl eligible after scoring a season-high in points during a 50-6 win over Northwestern last weekend, and the defense has allowed 20 or fewer points in 3 of the previous 4 outings. The Wolverines are 3-1 against the spread (ATS) in those 4 games.
Ohio State scored a massive 38-15 win over Indiana last weekend in a top-5 showdown in Columbus, its third such game of the season. The Buckeyes can clinch a spot in the Big Ten Championship game, and a rematch against Oregon, with a victory Saturday. The Buckeyes are also 3-1 ATS in the past 4 outings.
Rankings – US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports
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Michigan at Ohio State odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated Friday at 10 p.m. ET.
- Moneyline (ML): Michigan +750 (bet $100 to win $750) | Ohio State -1200 (bet $1,200 to win $100)
- Against the spread: Michigan +19.5 (-105) | Ohio State -19.5 (-115)
- Over/Under (O/U): 42.5 (O: -105 | U: -115)
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Michigan at Ohio State picks and predictions
Prediction
Ohio State 29, Michigan 16
Moneyline
Ohio State (-1200) will cost you 12 times your potential return, and that’s way too much risk and not enough reward, especially in a rivalry game. You can’t touch this, even as part of a multi-leg parlay.
PASS.
Against the spread
Roll with MICHIGAN +19.5 (-105), as even the most ardent Ohio State -19.5 (-115) fan knows this is too many points in one of the best rivalries in America.
While Buckeyes fans can hope that they cover, snapping a 3-game skid in the series, the Wolverines have had their number in previous seasons. There will be a ton of emotions early in the game, and Ohio State hasn’t been getting off to great starts in these big outings. It fell behind Indiana early, it fell behind Penn State early, heck, it even fell behind Northwestern early at Wrigley Field.
Over/Under
OVER 42.5 (-105) is the lean, but go lightly.
Woody Hayes and Bo Schembechler would be rolling over in their graves if they saw the Over is 10-0 in the past 10 meetings in this rivalry game. The winner has scored 42 points in 4 of the past 5 meetings, and the winner has notched 30 or more in each of the previous 10 installments.
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