Cleveland Cavaliers at Philadelphia 76ers odds, picks and predictions

Analyzing Wednesday’s Cleveland Cavaliers at Philadelphia 76ers odds and lines, with NBA expert picks, predictions and best bets.

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The Cleveland Cavaliers (12-0) visit the Philadelphia 76ers (2-8) Wednesday. Tip-off from Wells Fargo Center is set for 7:30 p.m. ET. Let’s analyze FanDuel Sportsbook’s NBA odds around the Cavaliers vs. 76ers odds and make our expert NBA picks and predictions for the best bets.

Season series: First meeting; tied 2-2 last season

Cleveland came away with a 119-113 win at the Chicago Bulls Monday but failed to cover as an 8-point favorite as the Under (236.5) hit. G Donovan Mitchell dropped a game-high 36 points and the Cavs forced 21 turnovers in the win. Cleveland is the eighth team in NBA history to start the season 12-0.

Philly was bested 111-99 as a 3.5-point home underdog by the New York Knicks Tuesday with the Under (213) cashing. The 76ers only made 37.6% of their field-goal attempts (31-for-83), while the Knicks shot 49.4% (44-for-81). C Joel Embiid made his season debut, finishing with 13 points, 3 rebounds and 5 assists in 26 minutes. The former 2022-23 MVP struggled from the field, going 2-for-11, but he did hit all 8 of his free throws. F Paul George led the 76ers with 29 points, while rookie G Jared McCain added 23 off the bench — the first-round draft pick out of Ducke scored a career-high 27 in a 107-105 OT home victory vs. Charlotte.

Cavaliers at 76ers odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list NBA odds. Lines last updated at 5:32 a.m. ET.

  • Moneyline (ML): Cavaliers -390 (bet $390 to win $100) | 76ers +310 (bet $100 to win $310)
  • Against the spread (ATS): Cavaliers -9 (-110) | 76ers +9 (-110)
  • Over/Under (O/U): 217.5 (O: -110 | U: -110)

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Cavaliers at 76ers key injuries

Cavaliers

  • Jarrett Allen (leg) questionable
  • G Sam Merrill (ankle) questionable
  • Max Strus (ankle) out

76ers

Not yet submitted, below from Tuesday’s game

  • Tyrese Maxey (hamstring) out

For most recent updates: Official NBA injury report.

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Cavaliers at 76ers picks and predictions

Prediction

Cavaliers 121, 76ers 110

Moneyline

PASS. 

The Cavaliers should be able to win this game despite my prediction that Embiid will be more like himself. However, Cleveland is not worth the risk of betting on as -390 favorites. Bet on the spread and/or total instead.

Against the spread

LEAN CAVALIERS -9 (-110).

With their straight-up records, it’s no surprise Cleveland has been the much better team against the spread this season. The Cars are 9-3 ATS, while the 76ers are 2-8.

The Cavs are also the much healthier team and are more in rhythm right now. Pair that with the fact that Cleveland features the top scoring offense in the league at 122.4 points per game and we have a recipe for Cleveland to win by double digits.

This is a lean because despite the Cavs’ strong ATS showing, they didn’t cover the spread in their last two wins and they are on the road.

Over/Under

BET OVER 217.5 (-110).

The Over has hit in 3 of Cleveland’s last 5 games and is 5-1 in the last 6 matchups between these squads.

As proven by their 122.4 PPG, the Cavaliers have the firepower to carry this game to hit the Over. Cleveland, despite having the twin towers of Allen and F Evan Mobley, has not been as great defensively as in recent years to start the season, further solidifying this bet.

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