Indiana at Michigan State odds, picks and predictions

Analyzing Saturday’s Indiana at Michigan State odds and lines, with college football expert picks, predictions and best bets.

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The No. 13 Indiana Hoosiers (8-0, 5-0 Big Ten) and the Michigan State Spartans (4-4, 2-3) meet Saturday at Spartan Stadium. Kickoff is scheduled for 3:30 p.m. ET (Peacock). Below, we analyze BetMGM Sportsbook’s college football odds around the Indiana vs. Michigan State odds, and make our expert college football picks and predictions.

The Hoosiers’ improbable run continued as Indiana improved to an undefeated record with a 31-17 victory over the Washington Huskies Oct. 26. They covered the spread as a 5-point home favorite, while the total stayed under 54 points. A key pick-6 from DB D’Angelo Ponds in the first quarter set the tone for the afternoon. QB Tayven Jackson hit WR Omar Cooper Jr. for a 42-yard touchdown in the 2nd quarter, and RB Justice Ellison powered through with 29 carries for 123 yards and a touchdown, sealing the win.

The Spartans dropped their 4th game in the last 5, losing to in-state rival Michigan 24-17 Oct. 26. They failed to cover as 3-point road underdogs, and the game went Over (38). QB Aidan Chiles finished with 189 passing yards and a touchdown, while RB Nate Carter added 118 rushing yards and a score, highlighting their offensive strengths despite the tough loss.

– US LBM Coaches Poll: Conducted by the American Football Coaches Association and USA TODAY Sports

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Indiana at Michigan State odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated at 8:45 a.m. ET.

  • Moneyline (ML): Indiana -350 (bet $350 to win $100) | Michigan State +260 (bet $100 to win $260)
  • Against the spread (ATS): Indiana -7.5 (-115) | Michigan State +7.5 (-105)
  • Over/Under (O/U): 53.5 (O: -110 | U: -110)

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Indiana at Michigan State picks and predictions

Prediction

Indiana 34, Michigan State 24

Moneyline

PASS.

Indiana (-350) will win this game, but I’m not going to bet $350 to win $100 in return. I’ll take my bet to the spread.

Against the spread

BET INDIANA -7.5 (-115).

Indiana heads into this matchup against Michigan State with plenty of momentum. The Hoosiers have been scoring consistently, covering the spread in 7 consecutive games, and enter with a solid 7-1 ATS record. Indiana’s balanced offense has been effective at sustaining drives, boasting a 51.28% third-down conversion rate and maintaining possession for over 31 minutes per game.

Michigan State, on the other hand, has seen its numbers decline against tougher opponents. Led by Oregon State transfer QB Chiles, who has thrown more interceptions (9) than touchdowns (7), the Spartans have struggled, especially in high-stakes moments. Michigan State ranks 91st in total offense, averaging 365 yards and 21 points per game, but it has allowed an average of 28 points over their last 4 matchups.

Despite the 7.5-point spread, Indiana’s track record and consistent scoring make it a strong pick to cover on the road once again.

Over/Under

BET OVER 53.5 (-110).

The 52.5-point total here slightly exceeds Indiana’s season game average of 49.5, reflecting its potent offense, which ranks 2nd nationally at 46.5 points per game. Michigan State’s defense has struggled, allowing 28 points per game over its last 4 matchups against tougher Big Ten competition. While the Spartans generally keep scores lower (3-5 O/U), Indiana has been consistently high-scoring, clearing 40 points in both road games, including a 56-point showing against Nebraska.

Indiana being 6-2 to the Over suggests a high-scoring game here, making it likely that this matchup will exceed the usual Big Ten grind. Back the Over in what could be a spirited offensive battle.

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