If those who set the NFL lines are correct, a record-setting number of home fans are going to leave NFL stadiums disappointed.
Of the 14 games on the Week 6 schedule, nine road teams are favored to win. The NFL doesn’t set the schedule based on home teams being favored, and Week 6 is the best proof of that we’ve seen this season.
Odds provided by BetMGM Sportsbook
San Francisco 49ers (-190) at Seattle Seahawks (+155)
The 49ers are solid road favorites (3.5 points at -110 for both teams). The 49ers have struggled out of the gate, but they have dominated their division the past few years. San Francisco will be prepared to take it to the Seahawks on a short week and climb another step out of the hole it’s dug. Take the 49ers and lay 3.5 points (-110).
Jacksonville Jaguars (+110) at Chicago Bears (-135)
The Bears are small home favorites (2 points at -110 for both teams). The Jags offense languished in September, and the Bears defense isn’t a great recipe for getting things on track. Chicago hasn’t allowed more than 21 points in a game this season, and there’s no reason to think Jacksonville will change that. Take the Bears and lay 3 points (-110).
Arizona Cardinals (+180) at Green Bay Packers (-225)
The Over/Under on this one is high (47.5 points at -110 for Over and Under). These are two or the more all-or-nothing offenses that can look like world-beaters one week and amateurs the next. This game screams of big plays and taking chances, which always lends itself to points. Take Over 47.5 points (-110).
Indianapolis Colts (+110) at Tennessee Titans (-125)
The Colts opened as one-point favorites and now they’re 2.5-point underdogs. That’s a big shift. It might mean Jonathan Taylor doesn’t play and the line-setters know it. Tennessee is brutal, and the Colts can’t start 0-3 in their division while expecting to have a sniff of the playoffs. Take the Colts on the moneyline (+110).
Houston Texans (-350) at New England Patriots (+260)
The Texans are big road favorites (7 points at -110 for both). The Drake Maye era begins, and Houston’s defense is going to make enough plays exploiting the debut to give C.J. Stroud a couple short-field opportunities. Take the Texans and lay 7 points (-110).
Tampa Bay Buccaneers (-190) at New Orleans Saints (+155)
The Buccaneers are solid road favorites (3.5 points at -110 for both teams). With Spencer Rattler getting the start, the veteran Bucs defense will have a field day. Take the Buccaneers and lay 3.5 points (-110).
Cleveland Browns (+350) at Philadelphia Eagles (-450)
The Eagles are the biggest favorite of the week (9 points at -110 for both). The Eagles are coming off their bye and should be at full strength, but nothing about the last 11 games says Philly should be favored by that much. Take the Browns plus 9 points (-110).
Washington Commanders (+240) at Baltimore Ravens (-300)
The Ravens are big favorites (6.5 points at -110 for both teams). Until somebody completely shuts down Jayden Daniels, I’m staying on the train that giving almost a full touchdown cushion is too much. Take the Commanders plus 6.5 points (-110).
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Los Angeles Chargers (-155) at Denver Broncos (+130)
The Chargers are 2.5-point road favorites Denver’s defense doesn’t get the credit it deserves, and it doesn’t deserve to get points at home on the “we dare you to bet on them” mantra. LA’s offense is still a work in progress. Take the Broncos on the moneyline (+130).
Pittsburgh Steelers (-160) at Las Vegas Raiders (+135)
The Steelers are decent road favorites (3 points at -110 for both teams). The Raiders have shown nothing to think that they can cover this number and score 13 points. That’s what they seem to be capable of, and that isn’t enough. Take the Steelers and lay 3 points (-110).
Detroit Lions (-160) at Dallas Cowboys (+135)
The O/U is the biggest of the week (52 points and -110 for both the Lions and Cowboys). There are too many scenarios by which the offenses take over the game and don’t let up. There may be 80 passes thrown in this one. Take Over 52 points (-110).
Atlanta Falcons (-275) at Carolina Panthers (+220)
The Falcons are strong road favorites (6 points at -110 for both teams). The Panthers are a team in flux at the moment, and the Falcons had a pretty stiff list of opponents to start the season. This should be the Falcons’ chance to not have a one-score game. Take the Falcons and lay 6 points (-110).
Cincinnati Bengals (-185) at New York Giants (+150)
The Over/Under is pretty stiff (48 points and -110 for both Over and Under). The Giants have played ugly at home, so a lot of points on their end doesn’t make a lot of sense. When 30-17 is still under the number? Yes, please. Take Under 48 points (-110).
Buffalo Bills (-145) at New York Jets (+120)
The Bills are favored on the road (2.5 points at -110 for both teams). Until Davante Adams shows up, the Jets offense is too punchless to protect its own turf. Days after firing their head coach, the Bills could be their worst nightmare. Take the Bills and lay 2.5 points (-110).