First look: Buffalo Bills at Houston Texans odds and lines

Looking at Sunday’s Buffalo Bills at Houston Texans Week 5 NFL odds, lines and trends. Here’s what you need to know.

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The Buffalo Bills (3-1) meet the Houston Texans (3-1) in a Week 5 Sunday tussle at NRG Stadium. The start time will be at 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the Bills vs. Texans odds, and make our expert NFL picks and predictions.

Buffalo, which had yielded just 20 points over its previous 2 games, was touched up for a TD in every quarter of a 35-10 loss at the Baltimore Ravens Sunday. The Bills went just 3 of 13 on 3rd downs and were outgained 427 yards to 236.

On Sunday, Houston bounced back from a Week 3 setback with its 3rd win by 4 points or fewer. Behind QB C.J. Stroud going 27 of 40 for 340 yards, the Texans defeated the Jacksonville Jaguars 24-20.

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Bills at Texans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 7:50 a.m. ET.

  • Moneyline: Bills +100 (bet $100 to win $100) | Texans -120 (bet $120 to win $100)
  • Against the spread (ATS): Bills +1.5 (-110) | Texans -1.5 (-110)
  • Over/Under (O/U): 46.5 (O: -115 | U: -105)

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2024 betting stats

  • ML: Bills 3-1 | Texans 3-1
  • ATS: Bills 2-2 | Texans 0-3-1
  • O/U: Bills 2-2 | Texans 1-3

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Bills vs. Texans head-to-head

Buffalo and Houston are meeting for the 1st time since 2021 and for the 12th time overall (includes 1 playoff game). The Texans are 5-2 across the last 7 meetings and lead the all-time series 6-5.

The Texans are 4-2 in games played at home; the 4 wins have been in the last 4 opportunities on home turf.

The last 4 overall meetings have seen Buffalo go 3-1 against the number. The Under has prevailed in 3 straight and is 6-1 across 7 meetings since 2009.

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