Updating an ongoing story, San Francisco 49ers RB Christian McCaffrey (calf, Achilles) was placed on the Reserve/Injured list on Saturday, Sept. 14. He is eligible to return in Week 6 at the Seattle Seahawks.
Fantasy football advice: After days of speculation, McCaffrey was placed on IR ahead of Week 2 action, which saves the team a game he was scheduled to miss anyway. The four-week absence means RB Jordan Mason will man the primary role of the backfield, and we could see a hint of RB Isaac Guerendo sprinkled in. However, after Week 1’s utilization, look for FB Kyle Juszczyk to get more opportunities than the rookie. Stash CMC as long as it takes, and be diligent on the waiver wire if you were unable to secure the services of Mason.