The Chargers had their final practice on Friday ahead of the Week 18 game against the Chiefs.
Wide receiver Keenan Allen, edge defender Joey Bosa, EDGE Justin Hollins and defensive tackle Nick Williams have been ruled out.
Allen finishes the season with 108 receptions for 1,243 yards and seven touchdowns.
Guard Zion Johnson and linebacker Kenneth Murray are doubtful.
Cornerback Deane Leonard, LB Tanner Muse, tight end Stone Smartt and EDGE Tuli Tuipulotu are questionable.
As for the Chiefs, WR Rashee Rice, CB L’Jarius Sneed, WR Kadarius Toney, and offensive tackle Donovan Smith are out.