First look: New York Giants at Buffalo Bills odds and lines

Looking at Sunday’s New York Giants at Buffalo Bills Week 6 NFL odds, lines and trends. Here’s what you need to know.

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The New York Giants (1-4) visit the Buffalo Bills (3-2) on Sunday Night Football in Week 6. Kickoff from Highmark Stadium is at 8:20 p.m. ET (NBC). Below, we look at Giants vs. Bills odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.

The Giants failed to cover as 13-point road underdogs in a 31-16 loss at the Miami Dolphins in Week 5. The Under (48) cashed in New York’s 3rd consecutive loss.

The Bills stumbled in London Sunday, losing 25-20 to the Jacksonville Jaguars as 5.5-point favorites. The loss snapped a 3-game win streak.

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Giants at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 8:26 a.m. ET.

  • Moneyline (ML): Giants +600 (bet $100 to win $600) | Bills -900 (bet $900 to win $100)
  • Against the spread (ATS): Giants +14.5  (-110) | Bills -14.5 (-110)
  • Over/Under (O/U): 46.5 (O: -110 | U: -110)

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2023 betting stats

  • ML: Giants 1-4 | Bills 3-2
  • ATS: Giants 0-5 | Bills 3-2
  • O/U: Giants 1-4 | Bills 2-3

Giants vs. Bills head-to-head

The Giants and Bills have faced each other only 14 times in an all-time series that dates back to 1970 and includes a meeting in Super Bowl XXV.  The series is split 7-7, but the Giants won the Super Bowl 20-19.

Buffalo won 28-14 when these teams met in 2019, covering as a 1-point favorite as the Under (44.5) cashed. New York had won the 3 previous meetings in 2007, 2011 and 2015.

Bills QB Josh Allen was the starter in that 2019 win. Giants QB Daniel Jones was on the Giants’ roster but was not the starter at the time.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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