The Indianapolis Colts (0-0) are set to host the Jacksonville Jaguars (0-0) at Lucas Oil Stadium on Sunday to officially commence the regular season.
While the Jaguars are solid road favorites in this opener, this game is likely going to come down to a handful of matchups on both sides of the ball. As rookie quarterback Anthony Richardson makes his first official start, there will be a number of matchups to keep an eye on.
Here are the key matchups to watch in Week 1 between the Colts and Jaguars: