Seattle Seahawks at Arizona Cardinals odds, picks and predictions

Analyzing Sunday’s Seattle Seahawks at Arizona Cardinals odds and lines, with expert NFL picks, predictions and best bets.

The NFC West-leading Seattle Seahawks (5-3) are on the road in Week 9 for a division game against the Arizona Cardinals (3-5). Kickoff is Sunday at 4:05 p.m. ET at State Farm Stadium in Glendale (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Seahawks vs. Cardinals odds, and make our expert NFL picks and predictions.

The Seahawks have won 3 straight games and 4 of five and lead the NFC West at 5-3. As 3-point home favorites last week, they won 27-13 behind QB Geno Smith’s 2 touchdown passes and a defense that allowed only 225 yards and forced 2 turnovers.

The Cardinals turned the ball over 3 times in the second half of their 34-26 road loss to the Minnesota Vikings in Week 8, failing to cover the 4-point spread. They are in last place in the division and have not won consecutive games all season. They lost 19-9 to the Seahawks in Week 6 on the road.

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Seahawks at Cardinals odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 6:24 p.m. ET.

  • Moneyline (ML): Seahawks +110 (bet $100 to win $110) | Cardinals -130 (bet $130 to win $100)
  • Against the spread (ATS): Seahawks +2.5 (-110) | Cardinals -2.5 (-110)
  • Over/Under (O/U): 49 (O: -108 | U: -112)

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Seahawks at Cardinals key injuries

Seahawks

  • Corey Blount (quad) questionable
  • WR Marquise Goodwin (groin) out
  • WR Penny Hart (hamstring) questionable
  • LB Darrell Taylor (groin) out

Cardinals

  • Budda Baker (ankle) questionable
  • RB James Conner (ribs) questionable
  • LB Dennis Gardeck (ankle) questionable
  • OL Rodney Hudson (knee) out
  • OL D.J. Humphries (back) questionable

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Seahawks at Cardinals picks and predictions

Prediction

Cardinals 23, Seahawks 20

Moneyline

The Cardinals and Seahawks have split their season series every year since 2019.

This game is essentially a must-win game for Arizona as a loss would drop them three games behind Seattle, give the Seahawks a head-to-head tiebreaker and would drop Arizona to 0-3 in the division.

The Cardinals have finally started scoring points, averaging 34 points the last two weeks, but they also have allowed 34 points each of the last two weeks.

They held tough in Seattle but did not score an offensive touchdown.

The return of WR DeAndre Hopkins has jumpstarted the offense.

The Seahawks, after allowing 34.5 points per game from Weeks 2-5, have allowed 15 per game in their three-game winning streak.

The Seahawks are playing better overall but the Cardinals find themselves in a desperate situation, which often changes outcomes.

I LEAN CARDINALS (-130).

Against the spread

The Seahawks are 5-3 ATS this season while the Cardinals are 4-4 ATS.

The Seahawks have failed to cover the spread in their last 4 games in November and are 1-9 ATS in their last 10 games following a contest in which they had fewer than 90 rushing yards. They had 87 last week against the Giants.

The Cardinals gave up 173 yards on the ground last week to the Vikings and are 5-1 ATS in their last 6 games following a contest allowing 150 or more rushing yards. However, they have failed to cover the spread in their last 5 NFC West games.

Again, desperation is the reason for this pick.

I LEAN CARDINALS -2.5 (-110).

Over/Under

The two teams combined for only 28 points in Week 6.

Half of Seattle’s games have had totals of fewer than 49 points. So have half of the Cardinal’s games.

BET UNDER 49 (-112).

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