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The 49ers have plenty at stake in their Week 8 clash with the Los Angeles Rams at SoFi Stadium.
Following back-to-back defeats, the Niners have gone from first to third in the NFC West at 3-4.
But, should they prevail and sweep the Rams, the 49ers will have a 3-0 record in the division and the tiebreaker over Los Angeles, a potentially crucial point in their favor in what looks set to be a tight division race.
Lose and drop to 3-5, and the Niners will be facing an uphill battle after the bye to secure a spot in the playoffs.
San Francisco will have to try to beat the Rams without the injured Deebo Samuel, the All-Pro wide receiver the headliner among a host of absentees. Here we look at the keys to the 49ers claiming triumph despite the loss of their best offensive player.