Best NFL underdog picks and predictions for Week 8

Analyzing NFL Week 8 betting odds and lines, with expert predictions and picks of the 3 best underdogs to cash in on.

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Six moneyline underdogs won their games outright in Week 7. Anyone who bet the Carolina Panthers or Chicago Bears had very nice payouts with their upset wins. There were 7 underdogs who covered the spread in their games last week.

Who will be the upset winners of Week 8?

Below, we analyze Tipico Sportsbook‘s NFL odds and lines, and tab the best NFL Week 8 underdog bets to cash in on among SportbookWire’s NFL expert picks and predictions.

My 3 top underdog picks went 2-1 last week, bringing my total underdog record to 10-11. Let’s see if we can at least even that record this week.

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NFL underdog predictions: Week 8

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at Thursday at 8:01 a.m. ET. All games Sunday and ET unless noted.

Arizona Cardinals (+160) at Minnesota Vikings – 1 p.m. (FOX)

The Vikings are 5-1 and coming off a bye, but their wins so far this season don’t scream really good team. They beat a struggling Packers squad handily in Week 1 and then they have 1-score wins over the Detroit Lions, New Orleans Saints, Chicago Bears and Miami Dolphins. Only the Dolphins have a winning record and they faced their 3rd-string quarterback.

The Cardinals have not won consecutive games all season and are coming off a win, but they got WR DeAndre Hopkins back in the lineup and should have RB James Conner and K Matt Prater ready to play this week.

Their defense has been solid all year and the offense should be even better than last week with a full week of practice for Hopkins.

Also see: All Week 8 odds and lines

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Los Angeles Rams (-103) vs. San Francisco 49ers – 4:25 p.m. (FOX)

The 49ers have won 7 straight regular-season matchups against the Rams, including a 24-9 win in Week 4 this season. But the 49ers will be without FB Kyle Juszczyk this week. He is the force behind the effectiveness of the Niners’ running game. WR Deebo Samuel also has been ruled out.

The Niners have lost 2 straight games.

The Rams are coming off their bye week so they are rested and had an extra week of preparation.

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New York Giants (+130) at Seattle Seahawks – 4:25 p.m. (FOX)

The Seahawks continue to be puzzling and the Giants continue to find ways to win, having won 4 straight games.

Seattle has scored 30 or more in 3 of their last 4 games, but will likely be without WR DK Metcalf, who has a knee injury.

The Seahawks are susceptible to the running game and the Giants, behind RB Saquon Barkley and the mobility of QB Daniel Jones, have rushed for 200 yards or more as a team 3 times this season and for more than 120 yards 5 times.

The Seahawks have allowed 27 or more points in 5 of their last 6 games and part of me just doesn’t trust what I have seen from Seattle this year.

More NFL Week 8 picks and predictions

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