The Indianapolis Colts (3-2-1) are coming off their first divisional win of the season and now will prepare for another AFC South matchup against the Tennessee Titans (3-2) in Week 7.
Finally showing signs of life on the offensive side of the ball, the Colts scored a season-high 34 points while quarterback Matt Ryan threw for 389 yards and three touchdowns. The Titans enjoyed their bye week.
As the top two teams in the division square off, the Colts will open as slight road underdogs to the Titans, according to Tipico Sportsbook.
| Spread | Moneyline | Total Points | |
| Indianapolis Colts (3-2-1) | +2.5 | +125 | O 42.5 -110 |
| Tennessee Titans (3-2) | -2.5 | -190 | U 42.5 -110 |
This matchup will be the final time the Colts and Titans square off during the regular season and the final time Indy will play a divisional opponent until ending the season with a home game against the Houston Texans.
It’s crucial for the Colts to even the series after losing 24-17 to the Titans in Week 4 at home. If they want to make a playoff push or even a push for the top spot in the division, coming away with a win is vital for the tiebreakers.
The Colts are hoping to see the return of running backs Jonathan Taylor and Nyheim Hines just in time for the offense to figure itself out with the quick-passing game.
Meanwhile, the Titans are going to be fresh coming off the bye week looking to complete the season sweep of their rivals.
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