The Buffalo Bills (4-1) head to GEHA Field at Arrowhead Stadium for Week 6 to face the Kansas City Chiefs (4-1). Kickoff is Sunday at 4:25 p.m. ET (CBS). Below, we look at Bills vs. Chiefs odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The Bills are coming off a 38-3 romp over the Pittsburgh Steelers in Week 5. QB Josh Allen had a field day against the Pittsburgh defense, throwing for 424 yards and 4 TDs while adding another 42 yards rushing. His favorite targets were WRs Gabe Davis (171 yards and 2 TDs receiving) and Stefon Diggs (102 yards and 1 TD receiving).
The Bills by far boast the league’s best point differential (+91), averaging 30.4 points per game while allowing just 12.2. Their lone loss this season came in Week 3 when they lost 21-19 on the road at the Miami Dolphins.
Also see: All Week 6 odds and lines
The Chiefs are coming off a thrilling 30-29 win over the division rival Las Vegas Raiders on Monday Night Football. TE Travis Kelce had a monster game with 4 TDs as the only Chiefs skill position player to find the end zone.
Kansas City boasts the league’s top offense with 31.8 points per game but ranks in the bottom 10 in defensive scoring by allowing 25 points per game. The Chiefs’ singular loss this season also came on the road in Week 3 against the Indianapolis Colts 20-17.
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Bills at Chiefs odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:40 a.m. ET.
- Moneyline (ML): Bills -130 (bet $130 to win $100) | Chiefs +110 (bet $100 to win $110)
- Against the spread (ATS): Bills -2.5 (-112) | Chiefs +2.5 (-108)
- Over/Under (O/U): 53.5 (O: -112 | U: -108)
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2022 betting stats
- ML: Bills 4-1 | Chiefs 4-1
- ATS: Bills 3-1-1 | Chiefs 2-3
- O/U: Bills 1-4 | Chiefs 3-2
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Bills vs. Chiefs head-to-head
The recent history between these squads has been super exciting. The Bills and Chiefs had one of the greatest playoff games in recent memory last year, with the Chiefs winning a 42-36 thriller. Down 3 points with 13 seconds left in the 4th quarter, the Chiefs had received the ball and managed to tie the game with a field goal, sending it to overtime where the Bills never had a chance to even touch the ball.
Overall, the Bills and Chiefs have faced 4 times during the Allen and Mahomes eras. The Chiefs are 3-1 during that span, going 3-1 ATS as well. The Over is also 3-1 during those matchups. Two of those games have come during the postseason, with the Chiefs winning and covering both.
Mahomes has earned 10 TDs, 2 INTs and 1 rushing TD during that 4-game span, along with averaging 300 yards passing per game. Allen’s numbers are similar, earning 11 TDs, 2 INTs and 1 rushing TD along with 263 yards passing per game.
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