First look: Ohio State at Michigan State odds and lines

Looking at Saturday’s Ohio State at Michigan State college football odds, lines and trends. Here’s what you need to know.

The Ohio State Buckeyes (5-0, 2-0 Big Ten) and Michigan State Spartans (2-3, 0-2) meet at Spartan Stadium Saturday in East Lansing. Kickoff is scheduled for 4 p.m. ET (ABC). Below, we look at Ohio State vs. Michigan State odds from Tipico Sportsbook; check back for all our college football picks and predictions.

The Buckeyes rolled up another big win over a conference foe last weekend, winning 49-10 against Rutgers. It is not only 2-0 inside the conference, but it has outscored its opponents 101-31 in those games. Ohio State has cashed the Over in 3 straight outings.

The Spartans started the season with 2 straight wins and covers and a high ranking, but Michigan State has dropped 3 games in a row while going 0-3 ATS during the skid. The Under is 4-1 in 5 games overall for Sparty.

Ohio State is No. 3 in the AFCA Coaches Poll powered by USA TODAY Sports.

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Ohio State at Michigan State odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 6:37 a.m. ET.

  • Moneyline (ML): Ohio State -2000 (bet $2,000 to win $100) | Michigan State +900 (bet $100 to win $900)
  • Against the spread (ATS): Ohio State -25.5 (-110) | Michigan State +25.5 (-110)
  • Over/Under (O/U): 61.5 (O: -110 | U: -110)

2022 betting stats

  • ML: Ohio State 5-0 | Michigan State 2-3
  • ATS: Ohio State 2-2-1 | Michigan State 2-3
  • O/U: Ohio State 3-2 | Michigan State 1-4

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Ohio State at Michigan State head-to-head

The Buckeyes lead the all-time series 35-15, including 6 straight wins dating back to a home loss Nov. 21, 2015. Ohio State punished Michigan State 56-7 in last season’s meeting and won 52-12 in its last visit to East Lansing Dec. 5, 2020.

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