Jacksonville Jaguars at Washington Commanders odds, picks and predictions

The Jacksonville Jaguars and Washington Commanders commence their 2022 seasons Sunday. Kickoff from FedExField is at 1:00 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Jaguars vs. Commanders odds, and make our expert NFL picks and predictions.

The Jaguars were a circus last season with coach Urban Meyer manning the ship, but they’ve since replaced him with a Super Bowl-winning coach in Doug Pederson.

Jacksonville QB Trevor Lawrence will be looking to prove why he was the No. 1 overall pick in the 2021 NFL draft with a new set of weapons that features RB Travis Etienne Jr. who has returned from injury and WRs Christian Kirk and Zay Jones who joined in the offseason via free agency.

The Commanders went 7-10 during the 2021 season, which saw them finish 3rd in the NFC East. Washington now has QB Carson Wentz operating the offense after QB Taylor Heinicke started in the majority of the games for the team a season ago.

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Jaguars at Commanders odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:35 a.m. ET.

Money line (ML): Jaguars +125 (bet $100 to win $125) | Commanders -150 (bet $150 to win $100)
Against the spread (ATS): Jaguars +2.5 (+105) | Commanders -2.5 (-130)
Over/Under (O/U): 43.5 (O: -117 | U: -103)

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Jaguars at Commanders key injuries

Jaguars

DE Foley Fatukasi (calf) questionable

Commanders

S Kamren Curl (thumb) out
TE Logan Thomas (knee) questionable

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Jaguars at Commanders picks and predictions

Prediction

Jaguars 24, Commanders 17

Money line

The Commanders are expected to defeat the Jaguars in the season opener, but I’m all-in on a much-improved squad for Jacksonville with Meyer no longer in the picture.

JAGUARS (+125) is the LEAN in this game, especially after defeating a Wentz-led Indianapolis Colts team in Week 18 of the 2021 campaign.

I’ll also take TREVOR LAWRENCE OVER 240.5 PASSING YARDS (-115) in this game due to the 2nd-year quarterback not having to worry about DE Chase Young (PUP) chasing him off of the edge for the Commanders.

Against the spread

Considering that I took the Jaguars to win the game outright, JAGUARS +2.5 (+105) is the choice here. All the ATS records Jacksonville had a season ago don’t matter with Pederson now at the helm.

The Commanders are 0-5 ATS in their last 5 games in September.

Over/Under

UNDER 43.5 (-103) is a solid pick in this matchup with games typically being ugly at FedExField. The Jaguars have a new-look offense that should perform much better in 2022 but they may need time to build chemistry, and it’s tough to trust Wentz on the Washington side.

The Under is 5-0 in Washington’s last 5 home games and the Under has hit in 9 of the last 12 games that the Commanders have appeared in.

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