The New York Giants open their regular season on the road against the Tennessee Titans for one of the late afternoon Sunday, Sept. 11, games. Kickoff is 4:25 p.m. ET (FOX) at Nissan Stadium. Below, we analyze Tipico Sportsbook‘s lines around the Giants vs. Titans odds and lines; check back for our NFL picks and predictions.
The Giants were 4-13 last year and finished last in the NFC East, leading to the hiring of a new coach and general manager. Brian Daboll now is tasked with turning the Giants around with QB Daniel Jones leading the offense.
Also see: All Week 1 odds and lines
The Titans begin the defense of their AFC South title last season. They went 12-5, but lost in the divisional round of the playoffs to the Cincinnati Bengals.
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Giants at Titans odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday, Aug. 29, at 12:23 a.m. ET.
- Money line (ML): Giants +190 (bet $100 to win $190) | Titans -240 (bet $240 to win $100)
- Against the spread (ATS): Giants +5.5 (-110) | Titans -5.5 (-110)
- Over/Under (O/U): 43.5 (O: -115 | U: -105)
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2021 betting stats:
- ML: Giants 4-13 | Titans 12-6
- ATS: Giants 6-11 | Titans 10-8
- O/U: Giants 5-11-1 | Titans 8-10
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Giants vs. Titans head-to-head
The Giants and Titans have faced each other 12 times in their history. The all-time series is tied 6-6, but the Titans have won 6 of the last 7 meetings.
Their last meeting was in 2018, a 17-0 Titans win.
Titans QB Ryan Tannehill is 1-0 against the Giants in his career.
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