The Chicago White Sox (42-45) and Cleveland Guardians (43-43) meet Wednesday to finalize a 4-game AL Central series. First pitch at Progressive Field is set for 7:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the White Sox vs. Guardians odds with MLB picks and predictions.
Season series: Cleveland leads 6-2.
The White Sox and Guardians split in Tuesday doubleheader. Chicago shut out Cleveland 7-0 in the nightcap after losing the opener 4-1. The White Sox have registered a fine 3.70 ERA in their last 17 games. For the season, Chicago ranks 21st in MLB with a 4.11 ERA.
On June 22, the Guardians were 8 games over .500 (36-28) and in 1st place in the AL Central. Since that date, Cleveland is just 7-15 and has been outscored 116-70.
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White Sox at Guardians projected starters
RHP Lucas Giolito vs. RHP Aaron Civale
Giolito (5-5, 5.05 ERA) has logged a 1.44 WHIP, 3.4 BB/9 and 10.7 K/9 through 82 IP in 15 starts.
- Has allowed 4 ER or more in 5 of his last 8 starts, but owns a 1.15 ERA in his last 5 starts against Cleveland.
- Has held lefty bats to a .675 OPS over his career (.608 this season), and that figures as a big key against a Cleveland club mashing right-handers from that side.
Civale (2-5, 6.28 ERA) is making his 12th start. He has a 1.45 WHIP, 2.6 BB/9 and 8.7 K/9 in 53 IP.
- Has a 5.06 ERA in his last 5 starts against Chicago.
- Took a Boeing 7.04 ERA into his last start (July 8 at Kansas City). Held the Royals to 1 run on 6 hits in 7 IP (0 BB, 6K).
White Sox at Guardians odds and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 10:17 a.m. ET.
- Money line: White Sox -115 (bet $100 to win $115) | Guardians -105 (bet $105 to win $100)
- Run line (RL): White Sox -1.5 (+145) | Guardians +1.5 (-180)
- Over/Under (O/U): 8.5 (O: +100 | U: -125)
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White Sox at Guardians picks and predictions
Prediction
White Sox 5, Guardians 3
Money line
The White Sox are 6-3 in their last 9 get-away games. Better control and an increasing ground-ball percentage of late are good signs for Giolito who has a good history against Cleveland and who has a solid history on the road (3.62 ERA since 2020).
CHICAGO (-115) IS A SOLID PLAY.
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Run line/Against the spread
Can’t wade through this juice to latch onto a good price. AVOID.
Over/Under
Both clubs have some underlying-analytics drag in their batting numbers. And Statcast quality-of-contact figures also call for both offenses to cool off.
Mix in 2 starting pitchers toting around batting averages on ball sin play in the .340s. On a cooled-off evening with an inward breeze helping the pitchers, TAKE THE UNDER 8.5 (-125).
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