Boston Red Sox at Chicago Cubs odds, picks and predictions

Analyzing Saturday’s Boston Red Sox at Chicago Cubs odds and lines, with MLB expert picks and predictions.

The Boston Red Sox (43-34) take on the Chicago Cubs (31-46) in the 2nd game of a 3-game series Saturday. First pitch from Wrigley Field is set for 7:15 p.m. ET (FOX). Let’s analyze Tipico Sportsbook‘s lines around the Red Sox vs. Cubs odds with MLB picks and predictions.

Season series: Cubs lead 1-0 following Friday’s 6-5 victory

After sweeping the Cleveland Indians in the first 3 games of their road trip, the Red Sox dropped 3 of their last 4 games – 2 at Toronto and Friday at Wrigley. They are 4-3 on the current road trip with 2 games to go.

The Cubs have won 4 of their last 5 games and are riding a 3-game winning streak. They are 6-3 in their last 9 games.

Red Sox at Cubs projected starters

RHP Josh Winckowski vs. RHP Alec Mills

Winckowski (3-1, 3.60 ERA) makes his 5th start. He has a 1.45 WHIP, 2.7 BB/9 and 5.9 K/9 through 20 IP.

  • On 3-game win streak after losing MLB debut May 28
  • Has a 2.12 ERA in last 3 starts, yielding just 4 ER in 17 innings

Mills (0-1, 9.87 ERA) makes his 2nd start in 7 appearances. He has a 1.73 WHIP, 3 BB and 10 K through 17 1/3 IP.

  • Will serve as an “opener” for a 2nd straight appearance
  • Has allowed 5 runs in each of his last 3 appearances – combined 8 1/3 IP

Red Sox at Cubs odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:13 p.m. ET.

  • Money line (ML): Red Sox -150 (bet $150 to win $100) | Cubs +122 (bet $100 to win $122)
  • Run line (RL)/Against the spread (ATS): Red Sox -1.5 (+105) | Cubs +1.5 (-130)
  • Over/Under (O/U): 9.5 (O: -108 | U: -112)

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Red Sox at Cubs picks and predictions

Prediction

Red Sox 7, Cubs 4

Money line

Even with the recent 3 losses in 4 games, the Red Sox are 23-18 on the road this season. Winckowski has been great in his last 3 starts.

The Cubs have struggled at Wrigley Field in 2022 as they sport a 16-26 home record. They have lost 5 of the 6 games that Mills has appeared in.

Take the RED SOX (-150).

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Run line/Against the spread

The Red Sox are 43-34 ATS on the season and 26-15 ATS on the road, the 4th-best mark in the majors. Nine of their last 12 wins have been by more than 1 run.

The Cubs are 19-23 ATS at home. Eleven of their last 12 losses have been by 2 or more runs.

Take the RED SOX -1.5 (+105).

Over/Under

Four of Boston’s last 5 games have had 10 or more runs, including Friday’s 6-5 series-opening loss to the Cubs.

Seven of the Cubs’ last 11 games have had 10 or more runs.

In 5 of the 6 games Mills has appeared, there have been double-digit runs.

Take OVER 9.5 (-108).

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