The San Francisco 49ers made it to the NFC Championship Game this last season as 1 of 3 teams in the NFC West to make the postseason. They eye another trip to the playoffs with second-year QB Trey Lance expected to lead the way as their starting quarterback in 2022.
Below, we look at the San Francisco 49ers 2022 NFL futures odds – including win total, division, conference and Super Bowl odds at Tipico Sportsbook – with best bet suggestions among our NFL picks and predictions.
The 49ers saw several starters depart in free agency this offseason — RB Raheem Mostert, OL Laken Tomlinson, DT D.J. Jones and CB K’Waun Williams.
They added CB Charvarius Ward and S George Odum as their most notable signings in free agency and then DE Drake Jackson in the NFL draft.
San Francisco 49ers’ 2022 schedule
| WK | DATE | OPPONENT | TIME (ET) |
| All times ET; *–At Mexico City | |||
| 1 | Sept. 11 | at Chicago Bears | 1 p.m. |
| 2 | Sept. 18 | vs. Seattle Seahawks | 4:05 p.m. |
| 3 | Sept. 25 | at Denver Broncos | 8:20 p.m. |
| 4 | Oct. 3 (M) | vs. Los Angeles Rams | 8:15 p.m. |
| 5 | Oct. 9 | at Carolina Panthers | 4:05 p.m. |
| 6 | Oct. 16 | at Atlanta Falcons | 1 p.m. |
| 7 | Oct. 23 | vs. Kansas City Chiefs | 4:25 p.m. |
| 8 | Oct. 30 | at Los Angeles Rams | 4:25 p.m. |
| 9 | BYE WEEK | ||
| 10 | Nov. 13 | vs. Los Angeles Chargers | 8:20 p.m. |
| 11 | Nov. 21 (M) | at Arizona Cardinals-* | 8:15 p.m. |
| 12 | Nov. 27 | vs. New Orleans Saints | 4:25 p.m. |
| 13 | Dec. 4 | vs. Miami Dolphins | 4:05 p.m. |
| 14 | Dec. 11 | vs. Tampa Bay Buccaneers | 4:25 p.m. |
| 15 | Dec. 15 (Th) | at Seattle Seahawks | 8:15 p.m. |
| 16 | Dec. 24 (Sa) | vs. Washington Commanders | 4:25 p.m. |
| 17 | Jan. 1 | at Las Vegas Raiders | 4:05 p.m. |
| 18 | Jan. 7 or 8 | vs. Arizona Cardinals | TBD |
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San Francisco 49ers’ 2022 win total: Best bet
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday, May 17 at 8:35 a.m. ET.
Over/Under: 9.5 (O: -150 | U: +125)
The 49ers won 10 games last season. They lost several starters and are moving on from QB Jimmy Garoppolo as they appear poised to turn to second-year QB Trey Lance to run the offense.
Coach Kyle Shanahan is 39-42 leading the 49ers. Garoppolo is 31-14 as a starter for the 49ers, which means Shanahan is 8-28 when he has someone other than Garoppolo starting.
Is Lance already ready to lead a playoff-contending team? That is the question.
I would not put money on the Over. I consider passing on this but I LEAN UNDER 9.5 WINS (+125).
San Francisco 49ers’ 2022 Super Bowl odds
Odds: +1500 (bet $100 to win $1,500)
The 49ers are firmly considered a contender for the Super Bowl following their run to the conference championship. Only 5 teams have shorter odds. The favorites to win the Super Bowl this next season are the Buffalo Bills (+600) and Tampa Bay Buccaneers (+700).
The Houston Texans have the longest odds at +20000.
At +1500, San Francisco has an implied probability of winning the Super Bowl of 6.25% or 15/1 fractional odds.
Conventional wisdom says that makes them worth at least a small wager to win it all. However, citing the 8-28 record the 49ers have since Shanahan became head coach when anyone other than Garoppolo starts, that isn’t a wager you can confidently make with Lance as the starter. This is not like Patrick Mahomes coming in as the starter for the Chiefs in his second season. He was a much more accomplished player than Lance was coming out of college.
PASS.
San Francisco 49ers’ 2022 playoff odds
Will 49ers make the playoffs: Yes -220 | No +175
San Francisco was one of the 3 wild card teams last season and did make it to the NFC Championship Game before losing to the eventual Super Bowl champion Los Angeles Rams.
The odds suggest overwhelming optimism they will return to the postseason. The price makes it such that it isn’t worth it to bet on them making it.
However, the price for the 49ers not making the playoffs is tempting.
You look at the losses they had in free agency and their history without Garoppolo as their start and you wonder why the odds are what they are. The teams expected to win their respective divisions are the Rams, Bucs, Packers and Cowboys. After them, the wild-card race really is wide open.
Unless Lance is much better than he was a season ago, you have to really look hard at them missing the playoffs. I LEAN 49ERS DO NOT MAKE THE PLAYOFFS (+175).
Odds to win NFC West Division
- Los Angeles Rams +135 (bet $100 to win $135)
- San Francisco 49ers +175 (bet $100 to win $175)
- Arizona Cardinals +320 (best $100 to win $320)
- Seattle Seahawks +1300 (bet $100 to win $1,300)
The 49ers are viewed as legitimate contenders for the NFC West title. The champion Rams with Matthew Stafford at quarterback and 3 stars leading the defense in Aaron Donald, Jalen Ramsey and Bobby Wagner are +135, while the 49ers are +175 with an unproven and largely untested young quarterback.
I am not optimistic. PASS.
Odds to win NFC
Odds: +650 (bet $100 to win $650)
Again, there are high hopes for the 49ers as only the Buccaneers, Rams and Packers have shorter odds. Their quarterbacks are Tom Brady, Stafford and Aaron Rodgers.
Do we really think that Lance will lead the 49ers over those teams and quarterbacks?
PASS.
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