The Arizona Cardinals (11-6) face the Los Angeles Rams (12-5) in the first Monday playoff game in NFL history as the NFC West rivals face off in an NFC Wild Card matchup. Kickoff is set for 8:15 p.m. ET at SoFi Stadium (on ABC and ESPN). Below, we look at the Cardinals vs. Rams odds and lines, and make our best NFL picks, predictions and bets.
The division foes split their two games this season with Arizona winning 37-20 at SoFi Stadium in Week 4, and Los Angeles claiming a 30-23 road victory in Week 14. The Cardinals started 7-0 but weathered injuries late in the season and lost four of their final five games to end up as the conference’s No. 5 seed.
The Rams lost their final game of the regular season but won their previous five. In his first season with the team, QB Matthew Stafford passed for 4,886 yards and 41 touchdowns. WR Cooper Kupp led the NFL in receiving yards (1,947), receptions (145) and touchdown catches (16).
Also see: Wild Card Weekend picks and predictions
Cardinals at Rams odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 8:48 p.m. ET.
- Money line: Cardinals +155 (bet $100 to win $155) | Rams -190 (bet $190 to win $100)
- Against the spread (ATS): Cardinals +3.5 (-110) | Rams -3.5 (-110)
- Over/Under (O/U): 49.5 (O: -115 | U: -105)
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Cardinals at Rams key injuries
Cardinals
- RB James Conner (ribs) questionable
- WR Rondale Moore (ankle) questionable
- DL Jordan Phillips (knee) questionable
- OL Justin Pugh (calf) questionable
- CB Marco Wilson (shoulder) questionable
Rams
- S Taylor Rapp (concussion) out
- WR Van Jefferson (shoulder) questionable
Let’s Make This Interesting
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Cardinals at Rams odds, lines, predictions and picks
Prediction
Cardinals 31, Rams 24
Money line
TAKE THE CARDINALS (+155) for the upset.
The Cardinals will be getting back some defensive reinforcements. They should have Wilson back in the secondary, and both Phillips and DE J.J. Watt, expected to be activated from injured reserve, on the interior. Watt and Phillips are the Cardinals’ two best interior rushers.
With the Rams secondary and linebacking corps shorthanded – down their two starting safeties and a starting linebacker – the Cardinals will be able to attack the middle of the field and pressure the L.A. defense.
In the Cardinals’ Week 4 win, they did not sack Stafford, but they did hit him several times, leading to erratic throws. Stafford (287 passing yards, 3 TDs) was nearly perfect in Week 14, but the Rams only won by seven points.
Against the spread
TAKE THE CARDINALS +3.5 (-110).
The Cardinals were 10-7 ATS overall and 8-1 ATS on the road this season. The Rams went 8-9 ATS in the regular season and 4-4 ATS at home.
Ten of the Rams’ 12 wins were over non-playoff teams. Against teams in the postseason, they went 2-5, while the Cardinals went 5-2 against playoff teams.
Over/Under
This one seems like a gimme. TAKE OVER 49.5 (-115).
Both games between the two teams went over 50 points.
Plus, the Cardinals scored 30 or more points in nine games this season, while the Rams did it seven times.
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