The Indianapolis Colts (8-6) will remain slight underdogs when they hit the road to visit the Arizona Cardinals (10-4) on Saturday night at State Farm Stadium.
Despite their big win over the New England Patriots, the Colts opened the week as underdogs to the Cardinals, who are tied with the second-best record in the entire NFL. As Saturday night approaches, the Colts will remain 1.5-point underdogs against the Cardinals in Week 16, per Tipico Sportsbook.
| Spread | Moneyline | Total Points | |
| Indianapolis Colts (8-6) | +1.5 | +103 | O 48.5 -115 |
| Arizona Cardinals (10-4) | -1.5 | -117 | U 48.5 -105 |
While the spread and moneyline remain the same from the opening odds this week, the total for the matchup dropped a point. That could be due to the fact that both teams are likely to be without their starting centers for the matchup.
Most of the experts around the league are siding with the Colts to win this matchup, but this is one that can’t be taken lightly. The Cardinals always have a chance to throw up 30 points with their explosive offense—even without DeAndre Hopkins.
It should be a fun matchup to watch as two explosive offenses go at it, and the Colts will remain underdogs for the prime-time game in the desert.
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