The No. 25 Kentucky Wildcats (8-3, 5-3 SEC) take on the Louisville Cardinals (6-5, 4-4 ACC) at Cardinal Stadium Saturday at 7:30 p.m. ET. Below, we look at the Kentucky at Louisville odds and lines; check back for our college football picks and predictions.
Kentucky is coming off its typical pre-rivalry-week tune-up, a 56-16 win over New Mexico State. The Wildcats had a successful SEC season thanks to a stout run defense (114.5 yards allowed per game; 18th nationally), though they’ve failed to cover in any of their last three conference games.
Louisville’s offense starts and ends with QB Malik Cunningham, who racked up 527 yards of total offense with 7 touchdowns (5 passing, 2 rushing) last week in a 62-22 drubbing of Duke. The Cardinals have the 16th-ranked offense in the country (459.1 yards per game), but they’re giving up 391.8 yards per game on the other side of the ball (77th nationally).
Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.
Kentucky at Louisville odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 6:53 a.m. ET.
- Money line: Kentucky +105 (bet $100 to win $105) | Louisville -130 (bet $130 to win $100)
- Against the spread (ATS): Kentucky +2.5, -115 (bet $115 to win $100) | Louisville -2.5, 105 (bet $105 to win $100)
- Over/Under (O/U): 56.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Kentucky 8-3 | Louisville 6-5
- ATS: Kentucky 7-4 | Louisville 6-5
- O/U: Kentucky 7-4 | Louisville 4-7
Kentucky at Louisville head-to-head
This will be the 33rd edition of the Governor’s Cup, with Kentucky holding a slight 17-15 edge all time. Kentucky has won the last two games of this rivalry, though the Wildcats and Cardinals didn’t play in 2020.
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