The Indianapolis Colts (4-5) will remain one of the biggest favorites across the league in Week 10 when they host the Jacksonville Jaguars (2-6) at Lucas Oil Stadium on Sunday.
The spread hasn’t shifted since opening earlier in the week so the Colts will enter the weekend as 10.5-point favorites over their division-mates in Week 10, per Tipico Sportsbook.
Here are the updated odds for the Week 10 matchup:
| Spread | Moneyline | Total Points | |
| Jacksonville Jaguars (2-6) | +10.5 | +400 | O 47.5 -108 |
| Indianapolis Colts (4-5) | -10.5 | -550 | U 47.5 -112 |
This will be the first time the Colts will face No. 1 overall pick Trevor Lawrence but it’s not likely to be the last. Though he’s struggled with consistency this season, the Colts have been a favorable matchup for quarterbacks.
Right in the thick of the playoff hunt for a wild-card spot, the Colts will need to make sure they take care of business before two tough road matchups against the Buffalo Bills and Tampa Bay Buccaneers, respectively.
As it stands entering the weekend, the Colts will be strong home favorites on Sunday.
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