The 2021 NFL season winds into Week 6 with four teams on a bye and just 14 games on the slate. USA TODAY Sports’ Lorenzo Reyes helps tee up this week’s biggest games with his NFL Week 6 locks. Watch Lorenzo’s Locks for his best bets of Week 6 and visit SportsbookWire.com for our NFL picks and predictions.
Also see: Week 6 staff picks
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list.
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