The San Francisco 49ers (2-2) will try to knock off the unbeaten Arizona Cardinals (4-0) in Week 5. This NFC West showdown kicks off Sunday at 4:25 p.m. ET at State Farm Stadium. Below, we look at the 49ers vs. Cardinals odds and lines, and make our best NFL picks, predictions and bets.
The 49ers started the season 2-0 but lost their last two games, most recently a 28-21 home loss to the Seattle Seahawks in Week 4. Rookie QB Trey Lance is set to make his first start in place of the injured Jimmy Garoppolo. San Francisco is seventh in the league in scoring but 22nd in points allowed per game.
The Cardinals are first in the league in points and total yards per game. QB Kyler Murray has thrown 9 touchdown passes and rushed for 3 more, and is third in the NFL in passing yards through four weeks. Arizona has allowed the ninth-fewest points in the league as opponents have only scored 30 second-half points against them.
49ers at Cardinals odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:35 a.m. ET.
- Money line: 49ers +180 (bet $100 to win $180) | Cardinals -230 (bet $230 to win $100)
- Against the spread (ATS): 49ers +4.5 (-107) | Cardinals -4.5 (-115)
- Over/Under (O/U): 48.5 (O: -108 | U: -112)
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49ers at Cardinals key injuries
49ers
- QB Jimmy Garoppolo (calf) out
- TE George Kittle (calf) doubtful
- CB K’Waun Williams (calf) out
- DT Javon Kinlaw (knee) questionable
Cardinals
- CB Byron Murphy (ribs) out
- CB Marco Wilson (ribs) questionable
- RB Chase Edmonds (shoulder) questionable
- RT Kelvin Beachum (ribs) questionable
- TE Maxx Williams (shoulder) questionable
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49ers at Cardinals odds, lines, predictions and picks
Prediction
Cardinals 34, 49ers 17
Money line
The 49ers have allowed 28 or more points in three of their four games, while the Cardinals scored over 30 points and 400 yards of offense in all four of theirs. Arizona has the largest point differential in the NFC.
The 49ers have two turnovers in three of their four games, while the Cardinals are third league-wide in takeaways.
Take the CARDINALS (-230).
Against the spread
The Cardinals are 3-1 ATS this season, compared to the 49ers’ 1-3 ATS record.
The Cardinals should be able to score at the rate they have been, and they have allowed 20 or fewer points in three of their four games.
Take the CARDINALS -4.5 (-115).
Over/Under
Both the Cardinals and the 49ers are 2-2 O/U, but all four games before this week for Arizona had projected totals in the 50s.
All four games for Arizona have also finished with totals in the 50s, despite the two Unders. Expect this one to just get there as well.
Take OVER 48.5 (-108).
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