The Arizona Cardinals (3-0) carry their unblemished record into Sunday’s matchup with the undefeated Los Angeles Rams (3-0), for a big early-season NFC West tilt at SoFi Stadium. Kickoff is set for 4:05 p.m. ET. Below, we look at the Cardinals vs. Rams odds and lines, and make our best NFL picks, predictions and bets.
The Cardinals are off to a fantastic start, winning each of their first three games. They lead the NFL in scoring with an average of 34.3 points per game, also checking in at No. 11 in total defense. QB Kyler Murray already has 10 total touchdowns and is averaging 335 passing yards per game, emerging as an MVP frontrunner in the early part of the season.
The Rams have been equally impressive. New QB Matthew Stafford has 9 touchdowns and just 1 interception, looking every bit like the star the Rams thought he’d be when they acquired him. The defense has played well, too, limiting the Tampa Bay Buccaneers to only 24 points – including a late garbage-time touchdown – last week.
Also see: Week 4 staff picks
Cardinals at Rams odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 5:15 p.m. ET.
- Money line: Cardinals +175 (bet $100 to win $175) | Rams -220 (bet $220 to win $100)
- Against the spread (ATS): Cardinals +4.5 (-108) | Rams -4.5 (-112)
- Over/Under (O/U): 54.5 (O: -105 | U: -115)
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Cardinals at Rams key injuries
Cardinals
- OT Kelvin Beachum (ribs) questionable
- OL Justin Murray (back) questionable
- OL Justin Pugh (back) questionable
- RB Eno Benjamin (hamstring) out
Rams
- RB Darrell Henderson Jr. (ribs) questionable
- WR Tutu Atwell (illness) doubtful
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Cardinals at Rams odds, lines, predictions and picks
Prediction
Rams 30, Cardinals 27
Money line
The Rams are 8-0 against the Cardinals since 2017 and have outscored them 251-91. It’s as lopsided as any head-to-head matchup of the last four seasons, with Los Angeles owning Arizona since Sean McVay took over as head coach.
This is a much better Cardinals team than the one the Rams crushed in the last four years, but Los Angeles is still the better group on paper and on the field.
Bet the RAMS (-220) to win outright at home.
Against the spread
The Rams and Cardinals are both 2-1 ATS, each with two double-digit wins and another by just 3 or fewer points. Although there have been seven double-digit wins by the Rams in the last eight games against Arizona, I expect this one to be closer.
Bet the CARDINALS +4.5 (-108) to cover the spread and keep this one within a field goal.
Over/Under
The total has gone Over in each of the Rams’ first three games, mostly because the offense has scored on more than half of their possessions thus far. The Cardinals have the highest-scoring offense in the league and can be susceptible to the run on defense, which is why the line is on the higher side.
Bet the OVER 54.5 (-105).
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