The Arizona Cardinals (2-0) seek their first 3-0 start to a season since 2015 as they head east to take on the Jacksonville Jaguars (0-2). Kickoff is at 1 p.m. ET at TIAA Bank Field. Below, we look at the Cardinals at Jaguars odds and lines, and make our best NFL picks, predictions and bets.
The Cardinals have put up 72 points in two games so far this season. They waxed the Tennessee Titans 38-13 in Week 1 on the road and barely survived a 34-33 home win over the Minnesota Vikings as K Greg Joseph missed a game-winning field goal as time expired.
QB Kyler Murray is an early MVP favorite with seven passing touchdowns and a pair of rushing touchdowns. He is the reigning NFC Offensive Player of the Week.
The Jaguars have begun the Urban Meyer era winless in two games. Rookie QB Trevor Lawrence, the No. 1 overall pick in the draft, has thrown five interceptions in his first two games. They are allowing an average of 30 points per game and 295.5 passing yards a game.
Cardinals at Jaguars odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 4:59 p.m. ET.
- Money line: Cardinals -380 (bet $380 to win $100) | Jaguars +290 (bet $100 to win $290)
- Against the spread (ATS): Cardinals -7.5 (-115) | Jaguars +7.5 (-107)
- Over/Under (O/U): 51.5 (O: -108 | U: -112)
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Cardinals at Jaguars key injuries
Cardinals
- OT Kelvin Beachum (ribs) questionable
- WR DeAndre Hopkins (ribs) questionable
- CB Marco Wilson (ankle) questionable
- CB Byron Murphy (ankle) questionable
Jaguars
- CB C.J. Henderson (groin) questionable
- CB Tre Herndon (knee) questionable
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Cardinals at Jaguars odds, lines, predictions and picks
Prediction
Cardinals 31, Jaguars 20
Money line
Picking the outright winner seems too easy. The Cardinals are undefeated and the Jaguars are winless. Kyler Murray is playing at an MVP level. Trevor Lawrence is playing like a rookie on a team short on talent. The Cardinals are 8-1 against the AFC South, dating back to 2013.
However, with the line at -380, there isn’t the value you would want in a bet. PASS and go with the spread or the total.
Against the spread
Arizona is 1-1 ATS while the Jaguars are 0-2 ATS to start the season.
The Cardinals look like playoff contenders early on, while the Jaguars look like they are a young team with a rookie quarterback and that needs more talent.
If the Cardinals are as good as they believe they can be, they should easily handle the Jaguars. They have put up 72 points in two games against bad defensive teams. The Jaguars are a bad defensive team right now. Expect at least 30 points from the Cardinals, and if that happens, the Jaguars simply aren’t equipped to keep up.
Take the CARDINALS -7.5 (-115).
Over/Under
The Cardinals just missed the Over in Week 1 and blew past it in Week 2. The Jaguars are also 1-1 O/U so far this season.
The Cardinals should crack 30 points. Can the Jags score enough to keep pace?
This one will be close, but the Cardinals should build a big lead and be able to coast to the end, electing to use the running game to eat the clock. Even if the Jaguars pick up a garbage-time score, it won’t likely be enough.
It will be close but take UNDER 51.5 (-112).
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