Arizona Cardinals favored at home vs. Buffalo Bills in Week 10

The Arizona Cardinals are the betting favorites in their Week 10 home game with the Buffalo Bills.

The Buffalo Bills (7-2) will head west next week to take on Kyler Murray and the Arizona Cardinals (5-3) Sunday in Week 10. Kickoff from State Farm Stadium is set for 4:05 p.m. ET. Below, we take a look at the early Week 10 betting odds and lines at BetMGM Sportsbook.

The Bills are coming off a statement win over the Seattle Seahawks, beating them 44-34 at home in Week 9 (Sunday). QB Josh Allen played a near-perfect game with 415 passing yards and four total touchdowns in the win. Buffalo has now won three in a row after dropping back-to-back games against the Tennessee Titans and the Kansas City Chiefs.

The Cardinals lost to the Miami Dolphins 34-31 in Week 9 – K Zane Gonzalez’s game-tying, 49-yard, field-goal attempt fell short with 1:58 remaining. Arizona had won three in a row prior to the loss, surging up the NFC standings. The Cardinals are sixth in scoring and fourth in yards per play.

Bills at Cardinals: Betting odds, spread and line

Odds via BetMGM; last updated Wednesday at 9:20 a.m. ET.

  • Money line: Bills +105 (bet $100 to win $105) / Cardinals -125 (bet $125 to win $100) | Bet now
  • Against the spread: Bills +1.5, -110 (bet $110 to win $100) / Cardinals -1.5, -110 (bet $110 to win $100) | Bet now
  • Total: 56.5, Over -110 (bet $110 to win $100) / Under -110 (bet $110 to win $100) | Bet now

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The Bills are the underdogs, being on the road against a quality opponent. They have an implied win probability of 48.8% with a money line of +105, meaning this game is expected to be close. With a +1.5 line, the Bills must lose by one point, tie Arizona or win outright in order to cover the spread.

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The Cardinals’ money line of -125 has an implied win probability of 55.6%, making them the favorites in this one. In order for them to cover the spread, they must beat the Bills by at least two points.

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