The Iowa State Cyclones (3-1 overall, 3-0 Big 12) and Oklahoma State Cowboys (3-0, 2-0) meet at Boone Pickens Stadium in Stillwater, Okla., for a 3:30 p.m. ET kickoff Saturday. Below, we analyze the Iowa State-Oklahoma State college football betting odds and lines, with picks and best bets.
The Cowboys are ranked sixth and the Cyclones are 18th in the Amway Coaches Poll powered by USA TODAY Sports.
Iowa State at Oklahoma State: Betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 3:51 a.m. ET.
- Money line: Iowa State +135 (bet $100 to win $135) | Oklahoma State -162 (bet $162 to win $100)
- Against the spread/ATS: Iowa State +3.5 (-115) | Oklahoma State -3.5 (-106)
- Over/Under: 52 (O: -110 | U: -110)
Iowa State at Oklahoma State: Three things to know
- After an opening 31-14 loss at home against Louisiana, the Cyclones have rattled off three consecutive victories inside the Big 12 and they’re flying high. The streak includes a 37-30 win over visiting Oklahoma on Oct. 3. Iowa State has covered two in a row, and is averaging 31.7 PPG across its three conference outings.
- The Cowboys routed Kansas 47-7 last time out, as the offense finally got started after a couple of sluggish outings to start. The run game is still doing its job, posting 212.3 rushing yards per game to check in 16th.
- Defensively, Oklahoma State has been on point, allowing just 274.7 total yards per game (7th in the nation), while allowing only 181.0 passing yards (13th), 93.7 rushing yards (10th) and 9.0 points (2nd) per game.
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Iowa State at Oklahoma State: Odds, prediction, betting lines and picks
Prediction
Oklahoma State 31, Iowa State 28
Money line (ML)
OKLAHOMA STATE (-162) is a decent play at home on the money line, although you’ll have to eat a moderate amount of chalk. But it’s a decent bet on a spread line of three and a hook, especially since Iowa State (+135) has a history of keeping it close against the Cowboys.
Against the spread (ATS)
IOWA STATE +3.5 (-115) is worth playing, especially with the hook, as it has the rush defense (100.8 yards per game) to at least keep Oklahoma State RB Chuba Hubbard’s production reasonable. If the Cyclones can force the Cowboys to pass, ISU could win this game outright. Iowa State has cashed in four of the past five in this series, and the underdog has covered five in a row.
Over/Under (O/U)
The OVER 52 (-110) is the play in this Big 12 showdown, and the Over has connected in four of the previous five in this series. Iowa State has a solid passing attack, and Oklahoma State finally got on track last time out, albeit against perennial doormat Kansas. This won’t be end-to-end action, but it will inch Over in the fourth quarter.
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