Arizona Cardinals at Carolina Panthers odds, picks and best bets

Previewing the Arizona Cardinals at Carolina Panthers Week 4 betting odds, spread and lines, with NFL betting picks, tips and best bets.

The Arizona Cardinals (2-1) visit the Carolina Panthers (1-2) Sunday at Bank of America Stadium in Charlotte at 1 p.m. ET. Below, we analyze the Cardinals-Panthers Week 4 matchup, including the betting odds, spread and lines, and look at the best NFL betting options.

Cardinals at Panthers betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 8 a.m. ET.

  • Money line: Cardinals -182 (Bet $182, win $100) | Panthers +155 (bet $100, win $155)
  • Against the spread/ATS: Cardinals -3.5 (-110) | Panthers +3.5 (-110)
  • Over/Under: 50.5 (O: -110, U: -110)

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Cardinals at Panthers game notes

  • Cardinals QB Kyler Murray has four passing touchdowns and four rushing touchdowns, and he averages 7.2 yards per rush.
  • Cardinals WR DeAndre Hopkins leads the NFL in receptions and receiving yards with 32 catches for 356 yards.
  • The Panthers will be without RB Christian McCaffrey, who is on injured reserve. He accounts for 223 yards of Carolina’s 1,117 total yards.
  • The Panthers allow opponents to convert on nearly 57% of their third downs.
  • The Cardinals average 25.7 points per game and the Panthers give up 27.0 points per contest.

Cardinals at Panthers key injuries

Cardinals

  • Budda Baker (thumb) out
  • S Chris Banjo (hamstring) doubtful
  • C Mason Cole (hamstring) questionable
  • WR DeAndre Hopkins (ankle) questionable
  • WR Christian Kirk (groin) questionable
  • CB Dre Kirkpatrick (head) questionable
  • LB Devon Kennard (calf) questionable
  • LB Tanner Vallejo (illness) questionable

Panthers

  • S Jeremy Chinn (hip) questionable
  • OG Dennis Daley (ankle) questionable
  • DT Yetur Gross-Matos (illness) questionable
  • OT Russell Okung (groin) questionable
  • DT Kawann Short (foot) probable
  • WR Curtis Samuel (elbow) probable

Cardinals at Panthers: Odds, betting lines, picks and prediction

Prediction

Cardinals 31, Panthers 26

Money line (?)

The Cardinals are 1-1 straight up in games in which they were favored. Carolina is 1-2 straight-up as underdogs. The Cardinals had a chance to win last week despite turning the ball over three times. Murray won’t throw three interceptions often, so the offense should easily put up points. Take the CARDINALS (-182).

Against the spread (?)

The line continues to move towards the Panthers. Arizona began the week -5.5, but the line has dropped to -3.5. The Cardinals have covered the spread in two of three games, including one of two games in which they were favored. Carolina has covered one of its three games – it was underdogs in all three. The Cardinals covered their one road game and the Panthers did not cover in their one home game so far this season. Take the CARDINALS -3.5 (-110).

Over/Under (?)

The Cardinals’ games have gone Under in all three so far this season. Carolina’s have gone Over in two of three. With a bad Carolina defense, a banged-up Arizona defense and two offensive units that can put up points, take the OVER 50.5 (-110).

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