After a Week 1 win over the New York Jets, the Buffalo Bills (1-0) will take on the Miami Dolphins (0-1) in Week 2. Kickoff at Hard Rock Stadium is 1 p.m. ET.
Bills at Dolphins betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday, 1:25 p.m. ET.
- Money line: Bills -239 (bet $239, win $100) | Dolphins +200 (Bet $100, win $200)
- Against the Spread/ATS: Bills -5.5 (-110) | Dolphins +5.5 (-110)
- Over/Under: 41.5 (O: -110, U: -110)
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Bills at Dolphins game notes
- The Dolphins scored the fewest points in the NFL in Week 1, putting up only 11 points against the Patriots.
- Miami’s defense did allow the fewest passing yards in the league in Week 1, surrendering only 140 yards to Cam Newton.
- The Bills already rank in the top 10 of every key defensive category after one week.
- The favorite is 5-1 ATS in the last six meetings between these teams.
- The Bills are 5-1 SU in their last six games against Miami.
Bills at Dolphins key injuries
Bills
- DE Jerry Hughes (calf) questionable/limited Thursday practice
- LB Matt Milano (hamstring) out
- LB Tremaine Edmunds (shoulder) out
- CB Josh Norman (hamstring) IR
Dolphins
- CB Xavien Howard (knee) questionable/limited Thursday practice
- CB Byron Jones (ankle) questionable/limited Thursday practice
- WR DeVante Parker (hamstring) game-time decision/limited Thursday practice
- LB Elandon Roberts (concussion) out
Bills at Dolphins: Odds, betting lines, picks and prediction
Prediction
Bills 21, Dolphins 13
Moneyline (?)
The Bills are heavy road favorites against their division foes, and for good reason. They looked strong in the season opener against the Jets and should take care of business once again against a rebuilding Dolphins team.
Sure, QB Ryan Fitzpatrick can string up some magic at times, but that’ll be hard against this Bills defense. Take the BILLS (-239) to win outright.
Against the Spread (?)
As 5.5-point favorites, the Bills come in with a similar line to the one they had in Week 1. They really shouldn’t have much trouble with the Dolphins, who only scored 11 points against an equally good Patriots defense in the season opener.
Take the BILLS +5.5 (-110) to cover and take care of the Dolphins on the road.
Over/Under (?)
The Over/Under is only 41.5 points, tied for the second-lowest total of the week. The Bills are usually a good bet to go under, with six of their last eight games dating back to 2019 doing so.
With an elite defense and an unimpressive offense on the other side in the Dolphins, this game has a good chance to go UNDER 41.5 (-110).
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