The Houston Astros (15-12) and San Diego Padres (17-12) face off in the final game of their series Sunday at 4:10 p.m. ET at Petco Park. Below, we analyze the Astros-Padres MLB betting odds and lines, with picks and best bets.
Astros at Padres: Projected starting pitchers
RHP Zack Greinke vs. RHP Adrian Morejon
Greinke: 1-0, 1.84 ERA, 25 K, 29 1/3 IP, 5 starts
- Greinke has not allowed a home run this season.
- He has only walked four batters in 29 1/3 innings.
Morejon: 0-0, 0.00 ERA, 3 IP, 4 K, 1 start
- In his only other appearance of the year, he pitched three hitless innings.
- Morejon was 0-0 in 2019 in five appearances with two starts. The righty gave up 9 ER in 10 ⅓ IP last season.
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Astros at Padres: Key injuries
(Get the latest injury news here.)
Astros
- LF Michael Brantley (quad) questionable
- 3B Alex Bregman (hamstring) out
- LF Yordan Alvarez (knee) out
Padres
- OF Tommy Pham (hand) out
- C Francisco Mejia (thumb) out
Also see: BaseballHQ Fantasy Baseball
Astros at Padres: Odds, lines, picks and betting tips
MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 11:35 a.m. ET.
Moneyline (ML)
The Astros are slightly favored at -115. The Padres are incredibly hot right now, having won six in a row and are slugging the ball. They have hit five grand slams in the last six games. The Astros had won nine in a row prior to their series in San Diego. Greinke is the perfect foil for the powerful Padres lineup. He has not allowed a homer this season while the Padres are essentially relying on their bullpen Sunday afternoon. Take the ASTROS -115.
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Run line/Against the spread (ATS)
The line is set here for the Astros at -1.5, although they are the underdog cover at +125, while the streaking Padres are +1.5 (-154). Here you should count on Greinke again to stymie the Padres. San Diego has been more reliable with the cover, going 16-13 against the run line, while Houston is 13-14. Go with the value here and take the ASTROS -1.5 (+125).
Over/Under (O/U)
The total is set at 8.5 runs, -110 on either side. Only one of Greinke’s starts has gone Over this season and that was the third game of the year. After that, it was four Unders. Take UNDER 8.5 RUNS (-110).
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