4. Drew Brees (3-0 vs. Jags as a member of the Saints)
While the New Orleans Saints and the Jaguars haven’t met much in their history, quarterback Drew Brees owns a spectacular record against them.
Brees is 3-0 against the Jaguars in a Saints uniform and 4-1 overall if you include his time with the San Diego Chargers. The Jaguars and the Saints last met in the 2019 season, however, Brees was out due to injury and the Saints would go on to win by the score of 13-6 with now Carolina Panthers quarterback Teddy Bridgewater earning the credit for the win.
Just like others to come on this list, Brees will be a walk-in for the Hall-of-Fame when he retires, so it is not outside the realm of possibility to lose to a quarterback of his skill. However, with a winning streak like that, you can’t blame the Saints for circling the Jags on their schedule.