RB Tevin Coleman
Coleman will see a heavier workload with Matt Breida likely out with an ankle injury. He was a non-factor when the 49ers last played Arizona on Halloween when he rushed for 23 yards on 12 carries. Coleman hasn’t done much for the offense since his outburst against Carolina three weeks ago when he finished with 118 scrimmage yards. He has just 98 scrimmage yards combined the last two games. With Breida out, Coleman needs to play closer to how he did against Carolina to help take weight off of Garoppolo’s shoulders.