WR Deebo Samuel

There could be a lot of pressure on the rookie with George Kittle likely out Sunday and Emmanuel Sanders questionable with a rib cartilage injury. Sanders is going to try and play, but his injury will likely limit him and make Samuel the de facto No. 1 receiver. That shouldn’t be an issue following his eight-reception, 112-yard performance against Seattle. Despite some drop issues, Samuel has been the most consistent receiver on the team all season, and shown he can be a go-to target for Garoppolo.