The 49ers need a win against the Colts. Falling to 2-4 and losing after the bye against a 2-4 Indianapolis club would send San Francisco down a 2021 path that only ends in disaster.
A strong team-wide is vital for the 49ers, who have myriad issues to iron out to get back to the playoff-caliber club they expected to be going into the year, big games from these six players are especially important: