LT Joe Staley and RT Mike McGlinchey

Opponents generally have one dominant edge rusher to keep an eye on, but Minnesota’s pair of defensive ends, Everson Griffin and Danielle Hunter, are two of the league’s best when they pin their ears back. Staley and McGlinchey will both get help at times, but they have to win some one-on-one matchups. If they can stymie Hunter and Griffin and allow the rest of the line to pave the way inside, it’ll open the entire playbook for Shanahan.