Week 13 vs. Bills
A Monday night home date with the Buffalo Bills doesn’t jump off the screen as a daunting matchup given Buffalo’s recent history. However, head coach Sean McDermott got the Bills to the playoffs last year and probably should’ve won their wild-card game in Houston. Their defense is excellent, and their offense should be improved after the addition of Stefon Diggs in an offseason trade with the Vikings. Quarterback Josh Allen always makes things interesting, but this isn’t going to be a game the 49ers can sleepwalk through.