Week 10 at Saints
The Saints make the list solely because they’re arguably the best team in the NFC. That said, a couple factors could wind up making this one a little easier for the 49ers. If fans aren’t allowed at games, the Superdome becomes less of a home-field advantage for the Saints. There’s also the Thursday night factor with the 49ers coming off a long week of rest after facing the Packers the previous week on Thursday Night Football. All of those things aside, New Orleans gave the 49ers fits last year, and all signs point to this being another epic showdown.