RB Jonathan Williams

Another week without running back Marlon Mack, another week the Colts hope to get another dominating performance out of Williams. In his second start since Mack suffered a fractured hand, Williams has a chance to string together three consecutive games with at least 100 rushing yards.

The former sixth-round pick had 116 yards against the Jacksonville Jaguars in Week 11 and then recorded 104 rushing yards against the Texans in Week 12 when he got the start. Much of his success will be determined by how the offensive line plays against the Titans’ stout defensive front led by Harold Landry and Rashaan Evans.

The Colts are likely to lean on Williams pretty heavily again as Mack misses another game, and his performance will certainly help determine the outcome.