The 49ers defense put together their best game of the season last week holding Aaron Rodgers and the Packers to eight points. Now they face the second step of their three-game stretch of great quarterbacks when they head to Baltimore to face Lamar Jackson, who presents a whole different challenge than Rodgers.

The defense will have its hands full with the high-powered Baltimore offense and another quarterback capable of racking up big yards on the ground. Here are the six players to watch on the 49ers defense:

DL Nick Bosa

Bosa had his first sack in the month of November against Green Bay. Sunday night also happened to be the 49ers’ first game of the month against a non-mobile quarterback. On Sunday, the 49ers face Jackson who might be the best mobile quarter in the league. It’s possible it’s a trend for Bosa that he struggles getting to mobile quarterbacks, but he was able to continue getting pressure in those three games without a sack. The 49ers will need help from the entire front seven to contain Jackson and it’ll start with Bosa getting home from the edge.