Best single-game defensive performance

Week 8: Nick Bosa vs. Panthers

This also stays after getting the nod at the halfway point. Bosa put on a show against the Panthers with three sacks and an interception. The No. 2 overall pick became the 22nd NFL player to notch three sacks and an interception in a game. He is the first 49ers defender on that list. While Bosa had a ton of productive weeks that didn’t culminate in any sacks, he put it all together in Week 8 to quantify his production on the stat sheet.