The 49ers’ 2022 schedule is set!
They’ll look to climb back to the top of the NFC West and back to the postseason with presumed starting quarterback Trey Lance at the helm for the first time.
San Francisco’s schedule features games against the AFC West, NFC South, along with the third-place finishers in the AFC East and NFC East.
Here’s a look at the schedule with dates, times and ticket information:
| Week | Date | Opponent | Time (PT) | ||
| 1 | Sept. 11 | at | Chicago Bears | 10:00 a.m. | Tickets |
| 2 | Sept. 18 | vs. | Seattle Seahawks | 1:05 p.m. | Tickets |
| 3 | Sept. 25 | at | Denver Broncos | 5:20 p.m. | Tickets |
| 4 | Oct. 3 | vs. | Los Angeles Rams | 5:15 p.m. | Tickets |
| 5 | Oct. 9 | at | Carolina Panthers | 1:05 p.m. | Tickets |
| 6 | Oct. 16 | at | Atlanta Falcons | 10:00 a.m. | Tickets |
| 7 | Oct. 23 | vs. | Kansas City Chiefs | 1:25 p.m. | Tickets |
| 8 | Oct. 30 | at | Los Angeles Rams | 1:25 p.m. | Tickets |
| 9 | Nov. 6 | Bye | |||
| 10 | Nov. 13 | vs. | Los Angeles Chargers | 1:25 p.m. | Tickets |
| 11 | Nov. 21 | at | Arizona Cardinals | 5:15 p.m. | Tickets |
| 12 | Nov. 27 | vs. | New Orleans Saints | 1:25 p.m. | Tickets |
| 13 | Dec. 4 | vs. | Miami Dolphins | 1:05 p.m. | Tickets |
| 14 | Dec. 11 | vs. | Tampa Bay Buccaneers | 1:25 p.m. | Tickets |
| 15 | Dec. 15 | at | Seattle Seahawks | 5:15 p.m. | Tickets |
| 16 | Dec. 24 | vs. | Washington Commanders | 1:05 p.m. | Tickets |
| 17 | Jan. 1 | at | Las Vegas Raiders | 1:05 p.m. | Tickets |
| 18 | TBD | vs. | Arizona Cardinals | TBD p.m. | Tickets |