San Francisco 49ers at New Orleans Saints
TV: 1 p.m. ET Sunday, Fox
Records: 49ers 10-2, Saints 10-2
Line: Saints by 2½
Satellite radio: 49ers feed on Sirius 105 (streaming 827), Saints feed on Sirius 83 (streaming 821)
49ers’ keys: They must find ways to run against an elite, run-stopping Saints defense. New Orleans hasn’t allowed a 100-yard rusher in its past 38 games (including the playoffs). San Francisco expects to get leading rusher RB Matt Breida back for this game.
Saints’ keys: Stopping the run; doing so forces the 49ers to lean on QB Jimmy Garoppolo, who ranks near the bottom third of the league in pass attempts but sits inside the top 10 in interceptions and fumbles. When the Saints’ offense has the ball, look for QB Taysom Hill on option plays in an attempt to mimic the success Ravens QB Lamar Jackson had against the 49ers.
Who wins? Defense wins championships, and the Saints are capable of shutting down the 49ers’ running attack and putting Garoppolo into an uncomfortable spot. It won’t be easy, but the Saints win this one in a street fight. Saints 22, 49ers 20
— John Sigler
Bal@Buf / Car@Atl / Cin@Cle / Was@GB / Den@Hou / Det@Min / Mia@NYJ / Ind@TB / LAC@Jax / Pit@Ari / KC@NE / Ten@Oak / Sea@LAR / NYG@Phi