Green Bay Packers at Buffalo Bills odds, picks and prediction

Analyzing Saturday’s Green Bay Packers at Buffalo Bills preseason Week 3 matchup, with NFL odds, lines, picks, predictions and best bets.

The Green Bay Packers (0-2) meet the Buffalo Bills (2-0) Saturday for a 1 p.m. ET kickoff at Ralph Wilson Stadium. Below, we look at the Packers vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Packers have struggled in the preseason falling to the Houston Texans by a 26-7 score Aug. 14, and 23-14 against the New York Jets Saturday. Green Bay posted just 143 passing yards and 135 rushing yards against the Jets.

The Bills rolled up 41 points in Chicago against the Bears last Saturday, the most points scored by any team so far this preseason. They also picked up a 16-15 win Aug. 13, on the road against the Detroit Lions.

Packers at Bills odds, spread and lines

Odds via Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 7:40 a.m. ET.

  • Money line: Packers +280 (bet $100 to win $280) | Bills -370 (bet $370 to win $100)
  • Against the spread/ATS: Packers +8.5 (-112) | Bills -8.5 (-108)
  • Total: 34.5 (Over: -112 | Under: -108)

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Packers at Bills odds, lines, picks and predictions

Prediction

Bills 24, Packers 13

Money line

The Bills (-370) will cost you nearly four times your potential return, and that’s not a good bet in the preseason, or otherwise.

AVOID and play the spread instead.

Against the spread

The BILLS -8.5 (-108) are likely to use QB Josh Allen very little, but backup QB Mitchell Trubisky shows how much depth Buffalo has at the position. Allen didn’t even play in the team’s 41-15 blowout win last weekend. Whether or not Allen plays, take the Bills.

QB Aaron Rodgers isn’t likely to play for the Packers, and if he does, it will be a cameo. QB Jordan Love (shoulder) is out with a shoulder, so the Pack doesn’t have a ton of depth at the position at the moment.

Over/Under

OVER 34.5 (-112) is worth a look, as the Bills offense has been on point with or without Allen. The Packers have struggled to put up points, as Rodgers has sat and Love has been injured, but the reserves could strike late to push this one over the top.

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