5 Best College Football Predictions Against The Spread: Week 0

What are the best bets and picks against the spread for the Week 0 start to the college football season?

5 best predictions for the start of the college football season. What games appear to be the best bets and the best picks for Week 0?


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CFN Experts Week 0 Picks
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Ahhhhhh yes, Week 0. The soft opening.

The college football season gets rolling for real next week, but first we all get up to speed with a modest slate of games that matter. There might not be a ton of massive games – or any – and there isn’t anything for the College Football Playoff chase.

But it’s college football, it counts, and you’re going to enjoy it.

There’s a limited number of games – usually this piece tries to pick from all the glut of options for a normal Saturday – but here are 5 best bets just in case you choose to invest this weekend.

We’ll start out with two for the price of one …

Click on each game for the preview

5. Wyoming at Illinois & Northwestern vs Nebraska point totals

LINE Wyoming vs Illinois 44, Northwestern vs Nebraska 49.5
Point Total Picks Under

No argument if you want to go over on these two games – you don’t win friends with the under – but …

It’s Week 0. We’re all guessing without any preseason to go off of. It’s a mistake to assume that 2021 will carry over to 2022 – new teams, new coaches in some sports, new schemes – but the general Week 0 theme is to go with what you know until proven otherwise.

Wyoming, Illinois, Northwestern, Nebraska – can any of them score?

44 is an obnoxiously low college football point total – 24-21 and you lose – considering it’s always possible that one team can hit that by itself, but until they show us something different, Wyoming and Illinois might struggle to get there.

This is more about the Cowboys. They rose up and rocked against a Utah State team that didn’t need the game late last year, and they hung up 52 on a Kent State defense that was but a polite suggestion, but they lost their key skill guys through the transfer portal, should bring a solid defense, and Illinois isn’t going to be an offensive juggernaut.

The Illini will do their part, though. Wyoming is going to struggle.

Northwestern and Nebraska in Dublin, Ireland, almost certainly isn’t going to be a firefight.

The Wildcats will try to grind this down, the defense should be far better than the version that gave up 56 to the Huskers last year, and 50 between the two might be asking for a lot.

After the big day against Northwestern, Nebraska failed to hit 30 points the rest of the way.

NEXT: College Football Pick Against The Spread No. 4 Northwestern vs Nebraska money line

Illinois vs Wyoming Prediction, Game Preview How To Watch Lines Week 0

Illinois vs Wyoming game preview, prediction, and breakdown for the Week 0 game on Saturday, August, 27

Illinois vs Wyoming prediction, game preview, how to watch. Week 0, Saturday, August 27


Illinois vs Wyoming How To Watch

Date: Saturday, August 27
Game Time: 4:00 ET
Venue: Memorial Stadium, Champaign, IL
How To Watch: BTN
Record: Illinois (0-0), Wyoming (0-0)
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Illinois vs Wyoming Game Preview

Why Wyoming Will Win

Does Illinois have an offense yet that can scare anyone?

The Illini were dead last in the Big Ten in passing, 115th in the nation in scoring, and 112th in total offense – and it was all worse than the numbers.

There’s hope with new offensive coordinator Barry Lunney Jr. and a likely new starting quarterback in Tommy DeVito from Syracuse, but this isn’t going to be the type of attack that walks onto the field and throws 45 up on the board.

Wyoming loves to play grinding, low scoring games that come down to ball control and tough defense, but …

Week 0 CFN College Football Expert Picks

Why Illinois Will Win

Few teams were hammered harder by the transfer portal than Wyoming.

Others can withstand a talent drain, but Wyoming isn’t Alabama – it hurts to lose WR Isaiah Neyor (Texas), Xazavian Valladay (Arizona State), its top quarterback options, a slew of key defensive backs, and on and on.

It’s not going to take much for the Illini to put this out of reach. Points might have been hard to come by last year, but two first quarter scores might be enough to get this done.

Score early, rely on the running game, assume the opposing offense can’t do a whole lot to bomb its way back, and beat Wyoming at its own game by being more grindy.

Week 0 College Football Schedule, Predictions, Game Previews

What’s Going To Happen

This is first time Wyoming has faced a Power Five program since opening up the 2019 season with a stunning 37-31 win over Missouri. However, the last win over a Power Five program on the road at Ole Miss in 2005.

This year’s Cowboy team might be well coached and won’t cheat anyone on the effort, but it’s going through too much of an overhaul. This won’t be anything pretty as Illinois will take over on the lines in the second half.

The running game will have a rough time early, but the dam will break half way through the third quarter.

All of the CFN Predictions

Illinois vs Wyoming Prediction, Line

Illinois 26, Wyoming 13
Line: Illinois -10, o/u: 44.5
ATS Confidence out of 5: 3.5

Illinois vs Wyoming Must See Rating: 2.5

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